Chức năng cơ bản của gan
- Tổng hợp protein huyết tương,
- Sản xuất các hormone,
- Lọc các xác tế bào hồng cầu, giải độc ,
- Sản xuất glucose và chuyển hóa lipid .
Vai trò của gan quan trọng trong việc duy trì tình trạng sức khỏe của con người có nghĩa là bệnh gan có thể ảnh hưởng nghiêm trọng tới tình trạng sức khỏe và đe dọa cuộc sống của con người.
Nguyên nhân căn bản gây bệnh cho gan
Nói chung, các loại bệnh: ung thư biểu mô tế bào gan (HC, ung thư gan), viêm gan, xơ gan, và gan nhiễm mỡ là những loại phổ biến nhất của bệnh gan. Trong số các bệnh này, ung thư gan và viêm gan là những vấn đề y tế công cộng toàn cầu phổ biến và nghiêm trọng nhất.
Bệnh viêm gan hoặc viêm gan gây ra bởi một trong những virus viêm gan (A, B, C, D, và E) là khá phổ biến.
Tổ chức Y tế Thế giới (WHO) ước tính rằng khoảng một phần ba dân số thế giới bị nhiễm virus viêm gan B (HBV) trong suốt cả cuộc đời, và khoảng 17,5% trở lên mãn tính, ước tính có khoảng 5% số này sẽ phát triển thành các bệnh gan nghiêm trọng như: xơ gan, và ung thư gan. Thống kê toàn cầu cho thấy việc nhiễm HBV làm cho hơn 1 triệu người chết mỗi năm .
Ung thư gan (trong đó bao gồm chủ yếu là một u gan ác tính) là loại ung thư phổ biến nhất. Nó xếp thứ ba trong các nguyên nhân tử vong liên quan tới ung thư trên thế giới. Theo thống kê của WHO, tỷ lệ mắc ung thư gan ở đàn ông cao hơn của phụ nữ khoảng 9 lần, và là căn bệnh phổ biến ở thế giới thứ ba.
Gan nhiễm mỡ không do rượu là một bệnh rất phổ biến của bệnh gan; nó có thể có ở hơn 70% số bệnh nhân tiểu đường type II, hơn 50% ở những người béo phì và gần 100% ở bệnh nhân có cả hai điều kiện.
Việc tiêu thụ nhiều rượu nặng, dẫn đến bệnh gan nhiễm mỡ do rượu và các loại ung thư khác nhau.
Nhiều nghiên cứu y học đã chứng minh vai trò quan trọng của hạt nhân tố-kappaB (NF-kB) đường tín hiệu, và stress oxy hóa trong sinh bệnh học của bệnh gan và đã chứng tỏ vai trò của chất chống oxy hóa trong chế độ ăn uống đối với bệnh gan.
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