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Tất cả các công trình dưới đây đều đã được cấp bằng sáng chế.
I. Điều trị ung thư
1. Ngăn ngừa hóa chất hoặc điều trị bệnh lý ác tính
Các chất chiết xuất từ thực vật Chi Lan Kim Tuyến A.formosanus và các thành phần có nguồn gốc từ nó được sử dụng như là các loại thuốc thảo dược hoặc các chất bổ sung dinh dưỡng để ngăn ngừa hóa chất (chemoprevention) hoặc điều trị bệnh lý ác tính của con người
Nghiên cứu này đã được cấp bằng sáng chế ở Mỹ (US 7033617 B2)
2. Kích hoạt phản ứng miễn dịch và chống khối u
Một nghiên cứu khác cung cấp bằng chứng cho thấy rằng ở chuột cấy tế bào khối u CT-26, khi cho uống dịch chiết nước của A. formosanus có thể kích hoạt phản ứng miễn dịch ở chuột, chẳng hạn như kích thích sự gia tăng của bạch huyết mô và kích hoạt thực bào của đại thực bào phúc mạc đối với các dấu hiệu tụ cầu khuẩn. Các hoạt động chống khối u của A. formosanus có thể được kết hợp với hiệu ứng tăng cường miễn dịch (immunostimulating) mạnh của nó.
Nguồn: Tseng CC1, Shang HF, Wang LF, Su B, Hsu CC, Kao HY, Cheng KT. PMID:16635745 [PubMed – indexed for MEDLINE]
3. Gây độc với các tế bào u tác động tích cực lên chu kỳ tự chết của tế bào
Một nhóm các nhà khoa học Trung Quốc cũng đã chứng minh chất chiết xuất từ thực vật A. formosanus. hoạt động gây độc tế bào với cơ chế cụ thể, trên các tế bào khối u, có liên quan đến sự cảm ứng của apoptosis ( chu kỳ tự chết của tế bào), tương tự như các cách thức và cơ chế tác dụng apototic trên tế bào ung thư gây ra bởi thuốc chống ung thư. Nghiên cứu này đã được cấp bằng sáng chế ở Mỹ, Úc và Singapore
Nguồn: Lie-Fen Shyur, Ning-Sun Yang, Pei-Ling Kang, Show-Jane Sun, and Sheng-Yang Wang . IP Status：Issued US 7,033,617B2, SG 120,937, TW pending, CN 100475753C, MY 142178-A, AU 2003244587B2
II. Tăng cường miễn dịch
Chi Lan Kim Tuyến có tiềm năng tăng cường hệ miễn dịch, các dịch chiết cho ra kết quả rất tốt.
1. Làm tăng bạch cầu hạt
Làm tăng bạch cầu hạt. Ngăn chặn việc giảm bạch cầu ở mô hình thử nghiệm chuột bị ung thư ruột kết CT – 26
Nguồn: Li-Chan Yang,1 Ting-Jang Lu,1 and Wen-Chuan Lin2 Taiwan. Received 19 June 2013; Revised 20 August 2013; Accepted 27 August 2013.
2. Kích thích các tế bào hỗ trợ T ( T healper ) type I và type II
Kích thích các tế bào hỗ trợ T ( T healper ) type I và type II. Số patent: 20120277182.
Xem thêm: http://www.faqs.org/patents/app/20120277182#ixzz3mWYC5jo2
3. Tăng sinh tế bào lympho B
Nguồn: Yen-chou Kuan , Tsai-jen Wu , Che-yu Kuo , Ju-chun Hsu , Wen-ying Chang , FuuSheu. Xem thêm: ftp.ncbi.nlm.nih.gov
4. Kích hoạt phản ứng miễn dịch: Gia tăng bạch huyết mô và kích hoạt thực bào của đại thực bào
Dịch chiết nước của A. formosanus có thể kí ch hoạt phản ứng miễn dịch ở chuột, chẳng hạn như kích thích sự gia tăng của bạch huyết mô và kích hoạt thực bào của đại thực bào phúc mạc đối với dấu hiệu tụ cầu khuẩn.
Nguồn: Tseng CC1, Shang HF, Wang LF, Su B, Hsu CC, Kao HY, Cheng KT. PMID:16635745 [PubMed – indexed for MEDLINE]
5. Kích thích các vi khuẩn có lợi cho đường ruột
Chiết xuất dung dịch nước và polysaccharide chậm tiêu hóa (AFP) từ Chi Lan Kim Tuyến formosanus cho thấy các hoạt động prebiotic có tác dụng kích thích tăng trưởng các vi khuẩn có lợi,tác động tích cực đến sức khỏe vi sinh vật đường ruột.
Nguồn: Yang LC; Lin WC; Lu TJ . Journal of agricultural and food chemistry 60:35 2012 Sep 5 pg 8590-9, Số Patent : 20120277182 .
Xem thêm: http://www.faqs.org/patents/app/20120277182#ixzz3mWYC5jo2
III. Bảo vệ gan và giải độc rượu
1. Bảo vệ gan một cách an toàn và hiệu quả
Một nghiên cứu đánh giá hoạt động bảo vệ gan của dung dịch nước chiết A. Formosanus dưới tác động của carbon tetrachloride, ethanol và paracetamol gây độc cho gan ở chuột, so sánh với silymarin (20 mg / kg) như là tiêu chuẩn tham chiếu cho thấy Dung dịch nước chiết xuất của Chi Lan Kim Tuyến formosanus đã cho thấy hoạt bảo vệ gan đáng kể so với silymarin tiêu chuẩn. Các nghiên cứu độc tính cấp đã kết luận rằng nó có thể được coi là an toàn trong một thời gian dài.
Nguồn: Amaresh Panda, Seemanchala Rath, Debashis Pradhan, Mahanty Debashis, Bijan Kumar Gupta, Nripendra Nath BalaInternational tại Journal of Pharmacy & Pharmaceutical Sciences;2014 Supplement 2, p617
2. Khả năng chống oxy hóa và tổn thương gan
Một nghiên cứu khác về khả năng chống oxy hóa và tổn thương gan gây ra bởi acetaminophen ở chuột cho thấy rằng dịch chiết A. formosanus có tác dụng chống oxy hóa. Trên mô hình gây độc bởi acetaminophen, mức tăng của aspartate aminotransferase (AST) và alanine aminotrans-ferase (ALT) đều giảm khi được xử lý bằng loại thảo dược này. Dịch chiết A.formosanus cũng bộc lộ ưu điểm khi trong quan sát mô học, tổng hoại tử ở thùy trung tâm, tắc nghẽn võng huyết quản, xâm nhập của các tế bào lympho và các tế bào Kupffer quanh tĩnh mạch trung ương gan, và việc mất ranh giới tế bào và phình thoái hóa đã giảm khi điều trị bằng dịch chiết A. formosanus.
Nguồn: Chung Ching Lin;Pei Chen Huang; Jer Min Lin; Kaohsiung, Taiwan
Xem thêm: http://www.worldscientific.com/doi/abs/10.1142/S0192415X00000118
3. Giảm nghiện rượu, bảo vệ gan
Các nhà khoa học Trung Quốc cũng đã công bố một sáng chế đã được cấp bằng sáng chế cho nghiên cứu: “Chi Lan Kim Tuyến formosanus: Giải pháp hỗn hợp uống đối với biện pháp giảm Nghiện rượu, Bảo vệ gan và Phương pháp Chuẩn bị chúng”
Xem thêm: http://www.chnpat.com/CN52/201210017037.html
4. Dược phẩm bảo vệ gan
Gần đây nhất,ngày 7/7/2015 công trình: “Chiết xuất dung dịch nước của Chi Lan Kim Tuyến ( kinsenoside), dược phẩm hữu ích cho bảo vệ gan” của các nhà khoa học Đài Loan đã được Mỹ cấp bằng sáng chế US9072770 B2
Xem thêm: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=9072770.PN.&OS=PN/9072770RS=PN/9072770
IV. Điều trị tiểu đường
1. Kích thích hấp thu glucose
Các nhà khoa học đã phân lập từ chi Lan Kim Tuyến một triterpene và năm hợp chất.
Các chất phân lập được đánh giá trên các tế bào HepG2 nhân kháng insulin để kích thích hoạt động hấp thu glucose. Kết quả cho thấy các hợp chất mới hiển thị hiệu ứng rất mạnh vào sự kích thích sự hấp thu glucose ở tế bào HepG2 ở người.
Nguồn: Jinyan Cai, Lin Zhao, En Zhu & Jiao Guo, p 2163-2168 Natural Product Research: Formerly Natural Product Letters Volume 28, Issue 23, 2014
2. Có kinsenoside chống mỡ máu, chống oxy hóa, chống viêm, tăng cường miễn dịch, bảo vệ gan, trị tiểu đường, trao đổi chất
Kinsenoside là một hợp chất hoạt tính sinh học cơ bản của Chi Lan Kim Tuyến formosanus.
Hoạt chất này có các hiệu ứng dược lý quý báu gần như toàn diện như chống mỡ máu, chất chống oxy hóa, chống viêm, tăng cường miễn dịch, và các hoạt động bảo về gan và có gần đây đã được phát triển như là một ứng cử viên thuốc trị đái tháo đường.
Nghiên cứu dược động học cho thấy: Kinsenoside có thể ổn định trao đổi chất cả ở chuột và vi lạp thể gan người.
Nguồn: Shaheed Ur Rehman, In Sook Kim, Min Sun Choi, Zengwei Luo, Guangming Yao, Yongbo Xue, Yonghui Zhang, and Hye Hyun Yoo1, Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of Korea 2; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, China
3. Nhiều hợp chất cho tác dụng điều trị tiểu đường
Để khám phá khả năng ức chế mạnh tyrosine protein phosphatase 1B (PTP1B) từ các loại thảo mộc toàn của Chi Lan Kim Tuyến để điều trị bệnh tiểu đường. Các nhà khoa học đã sử dụng chương trình Autodock để thử nghiệm. Kết quả là tất cả các hợp chất được thử nghiệm đã cho hoạt động ức chế của chúng chống lại PTP1B trong ống nghiệm. Nhiều hợp chất cho thấy tác dụng hoạt động ức chế mạnh.
Nguồn: Jinyan Caia*, Lin Zhaob & Weiye Taoc 22 Jan 2015 PMID: 25609152 [PubMed – in process])
Pharmaceutical Biology (Impact Factor: 1.34). 01/2015; 53(7). DOI: 10.3109/13880209.2014.957781
V. Chống loãng xương
1. Chiết xuất Chi Lan Kim Tuyến formosanus (arabinogalactan prebiotic) làm tăng hấp thu canxi và ngăn chặn sự tiêu xương ở chuột ovariectomized
Nguồn: Li-Chan Yang, Jin-Bin Wu, Ting-Jang Lu, Wen-Chuan Lin, British Journal of Nutrition, Volume 109 Issue 10, pp 1779-1788
2. Chống loãng xương
Nguồn: Shih CC et al, J Ethnopharmacol, 2001, 77:. 233-228)
VI. Bồi bổ cơ thể
Cho tới nay người ta đã nghiên cứu và phân lập được một số lượng lớn các chất trong Chi Lan Kim Tuyến như: Kinsenoside, glycosidic, adenosine, narcissin, v roseoside và triterpene…
1. Ảnh hưởng antihyperglycemic
Nguồn: Shih CC et al, Clin Exp Pharmacol Physiol, 2002 , 29: 684-688 .; JP7076522
2. Thuốc hạ lipid máu có hiệu lực
JP 6.293.655
3. Cải thiện trí nhớ và học tập
Nguồn: Cheng et al HY, J Chin Med, 2003, 14:.. 235-245
4. Ức chế quá trình oxy hóa của LDL
Nguồn: Shih CC et al, Am J Chin Med, 2003, 31:.. 25-36 – Mỹ Pat số 7.033.617
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